| Item Type | Name |
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Concept
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Adenosine Triphosphatases
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Concept
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RNA Precursors
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Concept
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RNA Splicing
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Concept
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RNA
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Concept
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RNA, Transfer
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Concept
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RNA Interference
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Concept
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RNA-Binding Proteins
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Concept
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RNA, Double-Stranded
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Concept
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RNA, Messenger
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Concept
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Single-Strand Specific DNA and RNA Endonucleases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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RNA, Complementary
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Concept
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RNA, Small Interfering
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Concept
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Sequence Analysis, RNA
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Academic Article
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
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Academic Article
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
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Academic Article
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
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Academic Article
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[Biogenesis of the insulin secretion granule].
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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Academic Article
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
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Academic Article
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
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Academic Article
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The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
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Academic Article
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
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Academic Article
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Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin.
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Academic Article
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
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Academic Article
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Characterization of the promoter for the rat and human link protein gene.
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Academic Article
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.
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Academic Article
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
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Academic Article
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Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules.
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Academic Article
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Alternative splicing generates two different mRNA species for rat link protein.
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Academic Article
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
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Academic Article
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
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Academic Article
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Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
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Academic Article
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Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension.
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Academic Article
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PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.
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Concept
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Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Concept
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RNA, Long Noncoding
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Concept
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3-Phosphoinositide-Dependent Protein Kinases
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Academic Article
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
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